His writings are among the most important in the history of western philosophy and science, and his influence on later thinkers has been incalculable: until the Renaissance they formed a major part of all European education. He was also appointed tutor to the future Alexander the Great. His first wife was Pythias, niece and adoptive daughter of his patron, King Hermeias of Atarneus and Assos. He later adopted Nicanor of Stagirus, Proxenus' son, who also married his daughter.